Photochemical Isolation of Nerve Grafts for Optimal Regeneration

Standard of care for nerve transection is primary suture repair using microsurgery, performed under magnification. Microsurgical attachment of nerves and nerve grafts is associated with a variety of problems. Our solution proposes to drastically reduce the suture burden and generate a full, water tight seal by photochemically bonding a crosslinked amnion wrap around the coaptation sites to fully seal the nerve. This study will execute a clinical trial to review four comparative arms: 1) Standard microsurgery using autologous graft; 2) Standard microsurgery using commercial allograft; 3) Photosealed repair with autologous graft; 4) Photosealed repair using commercial allograft.